Laga bilaabo Jannaayo 2020 ilaa Oktoobar 2020, cilmi baadhis habaysan oo mustaqbalka ah ayaa lagu qabtay Isbitaalka Jaamacadda Pisa kaas oo lagu daabacay BMC Microbiology.Goldstream®Fungus (1-3) -β-D-Glucan Tijaabada ayaa loo isticmaalay in lagu ogaado heerka BDG ee shaybaarada BAL.Natiijada waxaa lagu qiyaasey aAkhristaha Kinetic-ka Si Toos ah oo Dhameystiran IGL-200ka Era Biology.Cilmi-baaristu waxay muujinaysaa in BDG ay tahay in la tixgeliyo qiimaha saadaasha xun ee sarreeya.Waxayna keentay faa'iido leh in meesha laga saaro ogaanshaha PCP ee dhammaan bukaannada xakamaynta taban.
Asalkii hore:
Heerka dahabka ogaanshaha ee hadda jiraPneumocystis jiruveciiwaxaa lagu muujiyey muuqaal muuqaal ah oo fangaska ah oo laga soo qaaday shaybaarada neefsashada ee bukaan-socodka, sida dareeraha bronchoalveolar-lavage, oo qeexaya "la xaqiijiyay"P. jiroveciioof-wareenka, halka qPCR ay ogolaato in la qeexo ogaanshaha “malaha”, maadaama aysan awoodin inay takoorto caabuqa isticmaarka.Si kastaba ha noqotee, hababka molecular, sida PCR-dhamaadka iyo qPCR, aad bay u dhaqso badan yihiin, u fududahay in la sameeyo oo la tarjumo, sidaas darteed u oggolaanaya shaybaarka inuu dib ugu soo celiyo dhakhtarka xogta faa'iidada microbiological waqti gaaban.Daraasadda hadda jirta waxay ujeeddadeedu tahay isbarbardhigga microscopy iyo baaritaannada molecular iyo waxqabadka baaritaanka beta-D-glucan ee dareeraha bronchoalveolar-lavage ee bukaannada looga shakisan yahayPneumocystis jiruveciiburunkiito.Dareeraha Bronchoalveolar-lavage oo ka yimid siddeed iyo toban halis sare ah iyo afar maaddo oo xakameyn taban ayaa lagu sameeyay Grocott-Gomori's methenamine silver-staining, PCR-dhamaadka PCR, RT-PCR, iyo beta-D-glucan assay
Natiijooyinka:
Dhammaan shaybaarrada microscopically togan ee bronchoalveolar-lavage (50%) waxay sidoo kale natiijadeen togan marka la gaaro dhammaadka-dhamaadka iyo waqtiga dhabta ah PCR iyo dhammaan, laakiin laba, ayaa sidoo kale keenay togan sidoo kale qiyaasta beta-D-glucan.PCR-da-dhamaadka iyo RT-PCR waxay ogaadeen 10 (55%) iyo 11 (61%) 18-kii muunado, siday u kala horreeyaan, taas oo muujinaysa dareen la xoojiyey marka la barbar dhigo microscopy.Dhammaan RT-PCR oo leh Ct<27 ayaa si yar loo xaqiijiyay, halka muunado leh Ct≥ 27 aan ahayn.
Gabagabo:
Shaqadayadu waxay iftiiminaysaa baahida loo qabo dib-u-qaabaynta iyo dib-u-qeexidda doorka baadhista molecular ee goob caafimaad oo gaar ah, sidaP. jiroveciicaabuqa, kaas oo ah mid naadir ah laakiin sidoo kale aad u daran oo si degdeg ah u socda xaalad caafimaad oo saamaynaysa dadka difaaca jirka ah oo inta badan ka faa'iidaysan doona ogaanshaha degdega ah.Bukaannada si adag loo doortay, marka loo eego shuruudaha ka mid noqoshada, taasoo keentay diidmo hababka molecular ayaa laga yaabaa in laga saaroP. jiroveciiburunkiito.
Franconi I, Leonildi A, Erra G, iyo al.Isbarbardhigga hababka kala duwan ee microbiological ee ogaanshaha Pneumocystis jiruvecii oof wareenka ee dareeraha bronchoalveolar-lavage.BMC Microbiol.2022;22(1):143.La daabacay 2022 May 21. doi:10.1186/s12866-022-02559-1
Waqtiga boostada: Jun-14-2022