Baadhista KPC ee Carbapenem u adkaysata K-Set (Qalabka socodka dambe) Sawirka

Ogaanshaha KPC ee Carbapenem u adkaysata K-Set (Qiminta socodka dambe)

Nooca KPC ee CRE-da degdega ah 10-15 daqiiqo gudahood

Walxaha la ogaado	Enterobacteriaceae (CRE) u adkaysta Carbapenem
Habka	Baaritaanka socodka dambe
Tusaalaha nooca	Gumeysiga bakteeriyada
Tilmaamaha	25 tijaabo/xirmo
Koodhka badeecada	CPK-01

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Ogaanshaha KPC ee Carbapenem u adkaysta K-Set (Lateral Flow Assay) waa nidaam tijaabo ah oo immunochromatographic ah oo loogu talagalay ogaanshaha tayada ee nooca KPC-carbapenemase ee gumeysiga bakteeriyada.Qiimayntani waa shaybaadhka loo isticmaalo rijeetada kaas oo ka caawin kara ogaanshaha nooca KPC ee carbapenem adkaysi u leh.

Ogaanshaha NDM ee Carbapenem u adkaysta K-Set (Qaybta socodka dambe) 1

Astaamaha

Magaca	Ogaanshaha KPC ee Carbapenem u adkaysata K-Set (Qiminta socodka dambe)
Habka	Baaritaanka socodka dambe
Tusaalaha nooca	Gumeysiga bakteeriyada
Tilmaamid	25 tijaabo/xirmo
Waqtiga ogaanshaha	10-15 daqiiqo
Walxaha la ogaado	Enterobacteriaceae (CRE) u adkaysta Carbapenem
Nooca ogaanshaha	KPC
Xasilooni	K-Set-ku wuu xasiloon yahay 2 sano marka uu joogo 2°C-30°C

Faa'iidada

Degdeg ah
Ku hel natiijada 15 daqiiqo gudahood, 3 maalmood ka hor hababka ogaanshaha dhaqameed
Fudud
Shaqaalaha shaybaadhka caadiga ah waxay shaqayn karaan tababar la'aan
Sax ah
Dareen sare iyo gaar ahaaneed
Xadka ogaanshaha hooseeya: 0.50 ng/mL
Awood u leh inuu ogaado badi noocyada hoose ee caadiga ah ee KPC

Natiijo dareen leh
Natiijo akhris muuqaal ah, fudud oo cad
Dhaqaale
Alaabta waa la rari karaa laguna kaydin karaa heerkulka qolka, hoos u dhigista kharashyada

Muhiimadda imtixaanka CRE

Antibiyootigyada Carbapenem waa mid ka mid ah daawooyinka ugu waxtarka badan ee xakameynta bukaan-socodka ee caabuqa.Carbapenemase-producing organisms (CPO) iyo carbapenem u adkaysta Enterobacter (CRE) waxay noqdeen arrin caafimaad dadweyne oo caalami ah sababtoo ah caabbinta daawada ballaaran ee ballaaran, iyo fursadaha daaweynta bukaannada ayaa aad u xaddidan.Dadka adduunka oo dhan waa in ay fiiro gaar ah u yeeshaan ka hortagga fiditaanka CRE, taas oo, haddii aan la xaddidin, si dhab ah u saameyn doonta daaweynta bukaan-socodka ee cudurro badan, taas oo sii adkeynaysa daaweynta iyo xakamaynta cudurrada.

Caadi ahaan, bixiyeyaasha daryeelka caafimaadku waxay kaa caawin karaan ka hortagga faafitaanka CRE by

Si taxadar leh ula soco caabuqyada CRE ee xarumaha daryeelka caafimaadka
Kala sooc bukaannada qaba CRE
Ka saarida aaladaha caafimaadka ee ku jira gudaha jidhka, iyo yaraynta hababka daawaynta
Ka digtoonow marka aad qorayso antibiyootiko (gaar ahaan carbapenems), kaliya haddii runtii loo baahan yahay
Isticmaalka farsamooyin nadiif ah (madhalays ah) si loo yareeyo fiditaanka caabuqa

……
Dhammaan kuwan waxay muujinayaan muhiimadda ay leedahay ogaanshaha hore ee CRE.Si loo horumariyo badeecooyinka ogaanshaha degdega ah waxay muhiimad weyn u leedahay qoritaanka hore ee noocyada daawooyinka u adkaysta, hagida daawaynta, iyo hagaajinta heerarka caafimaadka iyo caafimaadka bini'aadamka.

nooca KPC-carbapenemase

Carbapenemase waxaa loola jeedaa nooc ka mid ah β-lactamase kaas oo ugu yaraan si weyn u hydrolyze imipenem ama meropenem, oo ay ku jiraan A, B, D saddex nooc oo ensaymes ah oo lagu kala saaro qaabka molecular Ambler.Fasalka A, sida nooca KPC-carbapenemase, ayaa ugu horrayn laga helay bakteeriyada Enterobacteriaceae.Klebsiella pneumoniae carbapenemase, oo loo soo koobay KPC, ayaa noqotay mid ka mid ah cudur-sidaha casriga ah ee ugu muhiimsan, halka daawaynta ugu fiicna ay tahay mid aan la qeexin.Caabuqyada ay sababaan KPC-yada waxay la xiriiraan guuldarada daweynta sare iyo heerka dhimashada ee ugu yaraan 50%.